Apse, Basilica of Santa Maria Maggiore, Rome
God's mouth emits the spiritus sanctus, punningly the Holy Spirit and "holy breath." Strikingly, God is pictured not as a hand or an old man but as the Son. Below, Gabriel greets Mary with the blessing gesture and she responds with a gesture that one historian says means reserve and detachment.
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Read more about the Annunciation.
Photographed at the basilica by Richard Stracke, shared under Attribution-NonCommercial-ShareAlike license.