Giovanni di Paolo di Grazia, The Annunciation

1445
National Gallery, Washington, D.C.

The Virgin Mary was thought of as the new Eve and the child about to be conceived as the new Adam, so the artist has added to the usual Annunciation iconography a scene of the angel expelling Adam and Eve from the Garden of Eden.

A further addition is St. Joseph, warming himself at a fire on the right.

Read more about the Annunciation.

Source: National Gallery of Art, Washington