4th century
Catacombs of Saints Peter and Marcellinus, Rome

Orpheus is a figure from pagan lore, but the catacomb is Christian, as are all its other images. Orpheus appears to have been chosen because he went into the underworld to save his wife. Christ did the same to save all the faithful, who constitute his "wife," the Church. Other paleo-Christian images overlay Orpheus iconography onto that of Christ as Good Shepherd.

Source: Wikimedia Commons