Duccio di Buoninsegna, The Descent from the Cross
Tempera on wood
Museo dell'Opera del Duomo, Siena, Italy
The man kneeling at right uses tongs to remove the nails from Jesus' feet while St. John and the man on the ladder gently lift him down. The Virgin Mary presses her face to his while St. Mary Magdalene kisses his arm.
The Virgin is dressed as usual in a red robe with a blue mantle. Those colore are reversed in Mary Magdalene's portrait.
This is a panel from the back of Duccio's Maestà, which follows Christ's Passion in 26 panels
Read more about the Descent from the Cross.
Source: Wikimedia Commons