Jacob Wrestles with the Angel
Nave, Basilica of Santa Maria Maggiore, Rome
See Genesis 32:24-30. This is part of the extensive series of Old Testament scenes portrayed in mosaics along the two walls of the nave. Follow this link for links to the others.
The original nave mosaics are form the 5th century, but several including this one appear to be from a later date, especially considering the attention to perspective and the modeling of the faces.
More of Jacob
Photographed at the basilica by Richard Stracke, shared under Attribution-NonCommercial-ShareAlike license.