The Descent from the Cross
Basilica of Sant'Abbondio, Como, Italy
Mary presses her face to her son's while St. Mary Magdalene raises her arms in an attitude more commonly seen in Crucifixion images
(example). The kneeling man may be untying Jesus' feet, a not uncommon detail in this period. He and the old man on the ladder are probably Nicodemus and Joseph of Arimathea, who take Jesus down in John 19:40. The young man on the right is certainly St. John the Evangelist.
More of the Descent from the Cross
More of the Crucifixion
Source: Wikimedia Commons